Link Biotech

RNA Synthesis

We provide high-quality siRNA, miRNA, sgRNA, custom RNA synthesis, and large-scale RNA synthesis services, as well as a variety of modification, fluorescent labeling, and delivery system conjugation services.

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What We Strive For

Link Biotech offers premium siRNA, miRNA, sgRNA, and custom RNA synthesis services tailored to diverse research needs. We design and synthesize RNA oligonucleotides in various lengths, formats, and chemical modifications, and also manufacture RNA sequences provided directly by customers. Our flexible synthesis scales range from 5 nmol, 10 nmol, and 20 nmol to large-scale production. All RNA products are HPLC-purified to eliminate truncated sequences generated during synthesis, ensuring superior purity and consistency. Backed by ISO 9001–certified facilities and detailed quality control documentation, we guarantee reliable, high-quality RNA products for research and development applications.

If you have any questions or for additional information on RNA synthesis services kindly contact us at support@linkbiotech.co.in OR linkbiotech@gmail.com

custom oligo synthesis

Featured RNA Synthesis

Custom siRNA Synthesis

Small interfering RNA (siRNA) consists of double-stranded RNA molecules approximately 20–25 nucleotides in length that trigger RNA interference (RNAi), a natural cellular process used to silence specific genes. By selectively suppressing or completely inhibiting target gene expression, RNAi has become a powerful tool in gene function studies and shows significant potential in the treatment of infectious diseases and cancer.

We offer comprehensive siRNA design and custom synthesis services, including both standard and chemically modified siRNA oligonucleotides, tailored to meet the specific requirements of our customers.

MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded RNA molecules approximately 22 nucleotides in length. They play a crucial role in regulating cell differentiation, biological development, and disease progression. As research into miRNA mechanisms advances, these molecules hold significant potential for driving innovations in diagnostics, drug discovery, and therapeutic development.

sgRNA (single guide RNA) serves as the core directive element of the CRISPR/Cas9 gene-editing system, precisely guiding Cas9 to targeted DNA sequences for accurate genome modification. Chemically synthesized sgRNAs exhibit low cytotoxicity, and their stability can be significantly improved through various chemical modifications, effectively minimizing off-target effects. Compared with in vitro–transcribed sgRNA and plasmid-based sgRNA, chemically synthesized sgRNA offers advantages including lower cost, higher gene-editing efficiency, and superior batch-to-batch consistency.

Link Biotech provides comprehensive sgRNA design and chemical synthesis services. All sgRNA products undergo mass spectrometry verification to ensure sequence accuracy and are purified by HPLC for high purity. We are dedicated to delivering sgRNAs with low toxicity, excellent batch consistency, and robust gene-editing performance.

Link Biotech deliver customized circRNA solutions with precise control over length and purity, tailored to meet a wide range of research requirements.

Why Choose circRNA Synthesis Services?

  • Dual-Platform Technology With both chemical synthesis and IVT platforms, we can produce circRNA of different lengths, modifications, and applications, ensuring flexibility for your research.
  • Chemical Synthesis Platform: Specializing in short circRNA segments (≤100 nt), we offer high-purity, high-yield, and fast-turnaround synthesis, ideal for miRNA sponges and functional fragment screening.
  • IVT Platform: Designed for efficient synthesis of long circRNA (≥200 nt), suitable for functional studies and drug development.

The delivery method and efficiency are the key factors for whether small nucleic acid drugs can enter cells and play a role. There are several delivery approaches, the naked RNA modification delivery technology, liposome nano-delivery technology, conjugated delivery system (small molecule ligands, antibodies, and other molecules), and other types of new delivery systems.

Link Biotech provides comprehensive RNA modification, labeling, and conjugation services to meet the needs of different types of nucleic acid drug delivery. Backed by expertise and innovation, we’re your partners in advancing research.

Link Biotech is committed to providing high-quality oligonucleotide products and services; we perform HPLC detection and provide COA files for all of our oligonucleotide products by default. There’s also a variety of customized QC service items to meet the specific needs of users.

Customized QC items (additional fee will be applied)

  • Molecular weight determination of oligonucleotides

  • Sequence confirmation of oligonucleotides

  • Impurity identification of oligonucleotides

  • Melting temperature (Tm) of oligonucleotide

  • IEX-HPLC Purity of Oligonucleotides

  • RP-HPLC Purity of Oligonucleotides

  • SEC-HPLC Purity of Oligonucleotides

  • Endotoxin content of oligonucleotides