| TNF alpha Antibody - Specification | |
| Synonyms | Tumor necrosis factor|Cachectin|TNF-alpha|Tumor necrosis factor ligand superfamily member 2 (TNF-a)|Tumor necrosis factor antibody, membrane form Alternative names: N-terminal fragment (NTF)|Intracellular domain 1 (ICD1)|Intracellular domain 2 (ICD2)|C-domain 1|C-domain 2|Tumor necrosis factor antibody, soluble form|TNF|TNFA|TNFSF2 antibody |
| Clonality | Polyclonal |
| Form | Liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Isotype | IgG |
| Immunogen | tumor necrosis factor(TNF superfamily, member 2) |
| Observed MW | 26 kDa |
| UniProt ID | P01375 |
| Recommended dilution | WB: 1:200-1:1000; IHC: 1:50-1:500 |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months |
TNF Alpha Antibody
| SKU Code | LBFN-003UA |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Tested Application | ELISA, IHC,WB |
| Size | 100μg |
| Price | POR |
Additional information
| Host | Rabbit |
|---|---|
| Reactivity | Human, Mouse, Rat |
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor(TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme(TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
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