| CASP3 Antibody - Specification | |
| Synonyms | Caspase-3 (CASP-3)|Apopain|Cysteine protease CPP32 (CPP-32)|Protein Yama|SREBP cleavage activity 1 (SCA-1)|Caspase-3 subunit p17|Caspase-3 subunit p12|CASP3|CPP32 antibody |
| Clonality | Polyclonal |
| Form | Liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Isotype | IgG |
| Immunogen | caspase 3, apoptosis-related cysteine peptidase |
| Observed MW | 32-35 kDa |
| UniProt ID | P42574 |
| Recommended dilution | WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200 |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months |
CASP3 Antibody
| SKU Code | LBFN-002UA |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Tested Application | ELISA, IHC, WB,IF,IP |
| Size | 100μg |
| Price | POR |
Additional information
| Host | Rabbit |
|---|---|
| Reactivity | Human, Mouse, Rat |
Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a ‘216-Asp-|-Gly-217’ bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. The antibody can recognize p17 and p32 of Caspase 3.
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