anti- Caspase 8 antibody

Catalogue No. 39210FNab
Size 100µg / liquid Form
Synonyms Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5
Host: Rabbit
Reactivity: Human, Mouse, Rat
Isotype: IgG
Tested Application: ELISA, WB, IHC, IP, IF
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Description

Product Name anti- Caspase 8 antibody
Catalogue No. 39210FNab
Size 100µg
Form liquid
Purification Immunogen affinity purified
Purity ≥95% as determined by SDS-PAGE
Host Rabbit
Clonality Polyclonal
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

BACKGROUND

Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibodycan recognize pro-and cleaved-caspase 8.

IMMUNOGEN INFORMATION

Immunogen caspase 8, apoptosis-related cysteine peptidase
Observed MW 50-55 kDa, 25-32 kDa

APPLICATION

Tested Application ELISA, WB, IHC, IP, IF
Recommended Dilution WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:100; IF: 1:10-1:100

IMAGES

Immunohistochemistry of paraffin-embedded human lymphoma using 39210FNab (CASP8 antibody) at dilution of 1:50
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HepG2 cells using 39210FNab (Caspase 8 Antibody)at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
IP Result of anti-CASP8 (IP:39210FNab, 3ug; Detection:39210FNab  1:500) with HeLa cells lysate 2500ug.
HepG2 cells were subjected to SDS PAGE followed by western blot with 39210FNab (CASP8 antibody) at dilution of 1:1000

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